Anti-Major Vault Protein (MVP) Monoclonal Antibody (Clone: 1014)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-36-3670-20 20 µg -

3 - 11 business days*

375.00€
ABE-36-3670-100 100 µg -

3 - 11 business days*

853.00€
 
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are... more
Product information "Anti-Major Vault Protein (MVP) Monoclonal Antibody (Clone: 1014)"
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plµg. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Protein function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [The UniProt Consortium]
Keywords: Anti-LRP, Anti-MVP, Anti-Major vault protein, Anti-Lung resistance-related protein, Anti-Major Vault Protein (MVP) Monoclonal Antibody (Clone: 1014)
Supplier: Abeomics
Supplier-Nr: 36-3670

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: 1014
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: proteins precipitated from human breast cancer MCF-7 cells

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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