Anti-Lymphotoxin beta Receptor (Lymphotoxin-beta Receptor, LT-beta-R, LTBR, CD18, D12S370, Tumor Nec

Human Lymphotoxin beta receptor (LTR, TNFSF3) is a member of the TNF receptor superfamily with similarilty to CD120a (TNFR1) and CD120b (TNFR2). It is a expressed mainly on non lymphoid tissues (1) and appears to have an important role in secondary lymphoid organ development (5). Suppression of LTR signaling can alleviate autoimmunity (2) or exasperate mycobacterial infection (6). Its ligands include Lt2 and LIGHT. In mice, LTR signaling is important for development and function of HEV (2), dendritic cells (3), and mast cells (4). Applications: Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.