Anti-LSD1 (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-contai

Anti-LSD1 (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-contai
Item number Size Datasheet Manual SDS Delivery time Quantity Price
L4595-50X.50 50 µg - -

1 - 19 business days

650.00€
 
LSD1, a novel and first known lysine-specific histone demethylase, nuclear protein belonging to... more
Product information "Anti-LSD1 (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-contai"
LSD1, a novel and first known lysine-specific histone demethylase, nuclear protein belonging to the flavin monoamine oxidase family with a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1, a component of several histone deacetylase complexes, is ubiquitously expressed in most of the tissues. A component of the CoREST and other transcriptional co-repressor complexes, LSD1 is known to play an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (possibly using alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: L4595-50X

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to 16aa from near the center of human LSD1 conjugated to KLH.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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