Anti-LL-37

Anti-LL-37
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15637-1 1 each -

6 - 10 business days*

422.00€
 
LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes,... more
Product information "Anti-LL-37"
LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes, gingival epithelium, and a variety of immune cells. It is produced by proteolytic cleavage of the cathelicidin human cationic antimicrobial protein of 18 kDa (hCAP18). LL-37 has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro. It functions as a chemoattractant for human monocytes, neutrophils, and T cells, and induces chemokine secretion from epithelial cells in infected tissues. LL-37 is a component of LPS-induced NETs produced from human neutrophils isolated from patients with systemic lupus erythrematosus (SLE) or individuals without SLE. It also enhances PMA- or S. aureus-induced formation of NETs. LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities. Native, but not citrullinated, LL-37 prevents mortality in a mouse model of D-galactosamine-sensitized endotoxic shock. Cayman's LL-37 Polyclonal Antibody can be used for Western blot.Synonyms: Antibacterial Protein LL-37. Immunogen: Synthetic human LL-37. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, conaining 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (+) hCAP18, () LL-37. UniProt Accession #: P49913.
Keywords: Anti-HSD26, Anti-CAP-18, Anti-hCAP-18, Anti-FALL-39 peptide antibiotic, Anti-Antibacterial peptide LL-37, Anti-Antibacterial peptide FALL-39, Anti-Cathelicidin antimicrobial peptide, Anti-18 kDa cationic antimicrobial protein
Supplier: Cayman Chemical
Supplier-Nr: 15637

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic human LL-37 antimicrobial peptide
MW: 5 kD
Format: Peptide Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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