Anti-LILRA5 (Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5, CD85 Antigen-like Family M

ILT11 is a 39-40kD Group 2 member of the LILR family of innate immune receptors. It is expressed on monocytes and perhaps neutrophils, and its activation results in the secretion of pro-inflammatory cytokines, such as TNF-A and IL-1B. Mature human ILT11 is a 258aa type I transmembrane glycoprotein. It has a 227aa extracellular domain aa42-268 that contains two C2 type Ig-like domains aa51-136 and 142-230, and a 10aa cytoplasmic tail. ILT11 has three potential splice forms. One is a 35kD soluble form of the molecule described above that shows a 27aa substitution for aa239-299. The other two splice forms are analogous to the above membrane and soluble forms, but demonstrate signal sequence cleavage further downstream after Ala51. Over aa41-268, human ILT11 shares 58% aa identity with mouse LIR-9. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul to label 1x10e6 human peripheral blood monocytes, Optimal dilutions to be determined by the researcher. Excitation: 488nm , Emission: 565-605nm, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.