Anti-Lats2

Anti-Lats2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F47336-0.08ML 80 µl - -

3 - 10 business days

207.00€
NSJ-F47336-0.4ML 400 µl - -

3 - 10 business days

503.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Negative regulator of YAP1 in the Hippo signaling... more
Product information "Anti-Lats2"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity). Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. [The UniProt Consortium]
Keywords: EC=2.7.11.1, Anti-Large tumor suppressor homolog 2, Anti-Serine/threonine-protein kinase kpm, Anti-Serine/threonine-protein kinase LATS2, Anti-Kinase phosphorylated during mitosis protein, Lats2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F47336-0.08ML

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: A portion of amino acids 1000-1027 from the mouse protein was used as the immunogen for this Lats2 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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