Anti-LATS2 (C)

Anti-LATS2 (C)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AC-R1974-2 100 µl - -

2 - 11 business days

338.00€
 
Preservative: 0.01% NaN3. Protein function: Negative regulator of YAP1 in the Hippo signaling... more
Product information "Anti-LATS2 (C)"
Preservative: 0.01% NaN3. Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. [The UniProt Consortium]
Keywords: Anti-KPM, EC=2.7.11.1, Anti-Warts-like kinase, Anti-Large tumor suppressor homolog 2, Anti-Serine/threonine-protein kinase kpm, Anti-Serine/threonine-protein kinase LATS2, Anti-Kinase phosphorylated during mitosis protein
Supplier: Abiocode
Supplier-Nr: R1974-2

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: C-terminal region of human LATS2
MW: 120 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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