Anti-LATS1/LATS2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-479A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A300-479A-M 100 µl (10 blots) -

3 - 9 business days

290.00€
A300-479A 100 µl (100 µg) -

3 - 9 business days

430.00€
 
Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal... more
Product information "Anti-LATS1/LATS2"
Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). [The UniProt Consortium]
Keywords: Anti-h-warts, EC=2.7.11.1, Anti-WARTS protein kinase, Anti-Large tumor suppressor homolog 1, Anti-Serine/threonine-protein kinase LATS1
Supplier: Bethyl Laboratories
Supplier-Nr: A300-479A-T

Properties

Application: WB, IP
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, X. Tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Gorilla, Chimpanzee, Duckbill Platypus, Tasmanian Devil, White-tufted-ear Marmoset, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-479A-T maps to a region between residues 1 and 50 of human Large Tumor Suppressor 2 using the numbering given in entry NP_055387.1 (GeneID 26524).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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