
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-CAB7159.100 | 100 µl | - | 9 - 20 business days | 429.00€ |
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WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Negative regulator of YAP1 in the Hippo... more
Product information "Anti-LATS1"
WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). [The UniProt Consortium]
Keywords: | Anti-h-warts, EC=2.7.11.1, Anti-WARTS protein kinase, Anti-Large tumor suppressor homolog 1, Anti-Serine/threonine-protein kinase LATS1, LATS1 Polyclonal Antibody (CAB7159) |
Supplier: | Antibody Genie |
Supplier-Nr: | CAB7159 |
Properties
Application: | WB, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant protein of human LATS1 |
MW: | 127 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08791 | Search using KEGG ID |
UniProt ID : | O95835 | Search using UniProt ID |
Gene ID | GeneID 9113 | Search using Gene ID |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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