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Protein function: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). [The UniProt Consortium]
Keywords:
Anti-ICE1, Anti-KIAA0947, Anti-Little elongation complex subunit 1, Anti-Interactor of little elongator complex ELL subunit 1
Human (Expected: Mouse, Rat, Bovine, Dog, Rabbit, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Chinese Hamster, Vampire Bat, Cat, Naked Mole Rat, African Elephant, Crab-eating Macaque, Thirteen-lined Ground Squirrel)
Immunogen:
synthetic peptide. The epitope recognized by A304-276A-T maps to a region between residue 1582 to 1632 of human KIAA0947 using the numbering given in entry NP_056140.1 (GeneID 23379)
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