Anti-Ki-67 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00375-T 10 µl (5+ slides) -

6 - 10 business days*

131.00€
IHC-00375 100 µl (50+ slides) -

6 - 10 business days*

493.00€
 
Protein function: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm... more
Product information "Anti-Ki-67 (IHC)"
Protein function: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. [The UniProt Consortium]
Keywords: Anti-Antigen Ki67 homolog, Anti-Antigen KI-67 homolog, Anti-Proliferation marker protein Ki-67, Anti-Antigen identified by monoclonal antibody Ki-67 homolog
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00375

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00375 maps to a region between residues1650 and 1700 of mouse Ki-67 using the numbering given in entry CAA58026.1 (GeneID 17345).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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