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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay13711-100 | 100 µg | - |
6 - 10 business days* |
530.00€
|
Ion channels are integral membrane proteins that help establish and control the small voltage... more
Product information "Anti-KCNQ1 Potassium Channel (Clone S37A-10)"
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels. Kv7.1 (KvLQT1) is a potassium channel protein coded by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying potassium) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction.Immunogen: Fusion protein amino acids 2-101 of human KCNQ1. Clone Designation: N37A-10. Formulation: (Request formulation change), 100 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.4, with 50% glycerol and 0.09% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ICC/IF, IHC, IP, WB. UniProt Accession #: P51787. Origin: Animal/Mouse.
Keywords: | Anti-KCNQ1, Anti-KCNA8, Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated channel subfamily KQT member 1, Anti-IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 13711 |
Properties
Application: | ICC, IHC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | S37A-10 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | fusion protein amino acids 2-101 of human KCNQ1 |
Format: | Purified |
Database Information
KEGG ID : | K04926 | Matching products |
UniProt ID : | P51787 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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