Anti-Kappa B Ras 1 (kB-Ras1, 2400004O09Rik, IkB-interacting Ras-like Protein 1, NFkB Inhibitor-inter

Anti-Kappa B Ras 1 (kB-Ras1, 2400004O09Rik, IkB-interacting Ras-like Protein 1, NFkB Inhibitor-inter
Item number Size Datasheet Manual SDS Delivery time Quantity Price
K0079-50.100 100 µg - -

3 - 19 business days*

498.00€
 
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is... more
Product information "Anti-Kappa B Ras 1 (kB-Ras1, 2400004O09Rik, IkB-interacting Ras-like Protein 1, NFkB Inhibitor-inter"
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: 293 Whole Cell Lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: K0079-50

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 8L509
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: This monoclonal antibody was raised against a synthetic peptide containing amino acid residues 96-113 of human kB-Ras1.
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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