Anti-JMY, NT (JMY, Junction-mediating and -regulatory protein) (Azide Free) (Biotin)

Anti-JMY, NT (JMY, Junction-mediating and -regulatory protein) (Azide Free) (Biotin)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
037210-Biotin.200 200 µl - -

3 - 19 business days*

993.00€
 
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics... more
Product information "Anti-JMY, NT (JMY, Junction-mediating and -regulatory protein) (Azide Free) (Biotin)"
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: Anti-JMY, Anti-Junction-mediating and -regulatory protein
Supplier: United States Biological
Supplier-Nr: 037210-Biotin

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: Biotin
Host: Rabbit
Species reactivity: human
Immunogen: JMY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from the N-terminal region of human JMY.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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