Anti-JMJD4, NT (Jumonji Domain-containing Protein 4, JmjC Domain-containing Protein 4)

Anti-JMJD4, NT (Jumonji Domain-containing Protein 4, JmjC Domain-containing Protein 4)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
J7876-53A.50 50 µg - -

1 - 19 business days

650.00€
 
Covalent modification of histones plays critical role in regulating chromatin structure and... more
Product information "Anti-JMJD4, NT (Jumonji Domain-containing Protein 4, JmjC Domain-containing Protein 4)"
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml , Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: J7876-53A

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to human JMJD4 at N-terminal conjugated to KLH.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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