Anti-IWS1, NT (Protein IWS1 Homolog, IWS1-like Protein, IWS1L)

Anti-IWS1, NT (Protein IWS1 Homolog, IWS1-like Protein, IWS1L)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I9901.100 100 µl - -

1 - 19 business days

496.00€
 
Various steps in gene expression, such as mRNA processing, surveillance, export, and synthesis... more
Product information "Anti-IWS1, NT (Protein IWS1 Homolog, IWS1-like Protein, IWS1L)"
Various steps in gene expression, such as mRNA processing, surveillance, export, and synthesis are coupled to transcription elongation (1,2). The C-terminal domain (CTD) of the large subunit of RNA polymerase II plays an important role in the integration of these different steps (1,2). IWS1 interacts with Spt6, a CTD-binding transcription elongation factor and H3 chaperone (1,2). IWS1 also recruits another CTD-binding protein, HYPB/Setd2 histone methyltransferase, to the RNA polymerase II complex for elongation-coupled H3K36 trimethylation (2). Thus, IWS1 links Spt6 and HYPB/Setd2 in a large complex and regulates mRNA synthesis and histone methylation at the co-transcriptional level (2). Applications: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunofluorescence (IF-IC): 1:200, Western Blot: 1:1000, Immunoprecipitation: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-IWS1-like protein, Anti-Protein IWS1 homolog
Supplier: United States Biological
Supplier-Nr: I9901

Properties

Application: IF, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues near the amino terminus of human IWS1.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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