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This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by... more
Product information "Anti-ITPR1"
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. Protein function: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. [The UniProt Consortium]
Keywords: | Anti-ITPR1, Anti-IP3R 1, Anti-InsP3R1, Anti-INSP3R1, Anti-Type 1 InsP3 receptor, Anti-IP3 receptor isoform 1, Anti-Type 1 inositol 1,4,5-trisphosphate receptor, Anti-Inositol 1,4,5-trisphosphate receptor type 1, ITPR1 Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-65565 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | A synthetic peptide of human ITPR1 |
Database Information
KEGG ID : | K04958 | Matching products |
UniProt ID : | Q14643 | Matching products |
Gene ID | GeneID 3708 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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