Anti-Irf3, NT (Irf3, Interferon regulatory factor 3) (Azide free) (FITC)

Anti-Irf3, NT (Irf3, Interferon regulatory factor 3) (Azide free) (FITC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
037103-FITC.200 200 µl - -

3 - 19 business days*

993.00€
 
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a... more
Product information "Anti-Irf3, NT (Irf3, Interferon regulatory factor 3) (Azide free) (FITC)"
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity). Applications: Suitable for use in Western Blot, FLISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-Irf3, Anti-IRF-3, Anti-Interferon regulatory factor 3
Supplier: United States Biological
Supplier-Nr: 037103-FITC

Properties

Application: FLISA, WB
Antibody Type: Polyclonal
Conjugate: FITC
Host: Rabbit
Species reactivity: mouse
Immunogen: MOUSE Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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