Anti-Irf3, NT (Irf3, Interferon regulatory factor 3)

Anti-Irf3, NT (Irf3, Interferon regulatory factor 3)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
037103.200 200 µl - -

3 - 19 business days*

728.00€
 
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a... more
Product information "Anti-Irf3, NT (Irf3, Interferon regulatory factor 3)"
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity). Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. , Recommended Dilutions: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Irf3, Anti-IRF-3, Anti-Interferon regulatory factor 3
Supplier: United States Biological
Supplier-Nr: 037103

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse
Immunogen: MOUSE Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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