Anti-IRF2

Anti-IRF2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30916 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interferon regulatory factor 2 is a member... more
Product information "Anti-IRF2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interferon regulatory factor 2 is a member of the interferon regulatory transcription factor (IRF) family. The IRF2 gene is mapped on 4q35.1. When the gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. One IRF binding site was found within the IRF2 promoter, and expression of the gene was affected by both transient and stable IRF1 expression. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. IRF2 was required to prevent NK-cell apoptosis and keep immature NK cells alive, thus promoting NK-cell maturation and their supply to peripheral blood. Protein function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. [The UniProt Consortium]
Keywords: Anti-IRF2, Anti-IRF-2, Anti-Interferon regulatory factor 2, IRF2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30916

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: An amino acid sequence from the C-terminus of human Interferon regulatory factor 2 (RPHWRKRNIEGKQYLSNM) was used as the immunogen for this IRF2 antibody (100% rat homology).
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-IRF2"
Write a review
or to review a product.
Viewed