Protein function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. [The UniProt Consortium]
Human, Mouse (Expected: Rat, Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, White-tufted-ear Marmoset, Sooty Mangabey, Crab-eating Macaque, African Elephant, Chinese Hamster, Golden Hamster, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A303-380A-T maps to a region between residue 150 and 200 of mouse Interferon Regulatory Factor 2 using the numbering given in entry NP_032417.3 (GeneID 16363).