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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I8604-16.100 | 100 µg | - | - |
3 - 19 business days* |
644.00€
|
Description: |Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the... more
Product information "Anti-IRE1p, CT (Inositol-Requiring Protein 1, IRE1a, Endoplasmic Reticulum-to-Nucleus Signaling 1, E"
Description: , Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94 (1,2). These proteins are normally bound to ER transmembrane proteins such , as IRE1p and ATF6 (3,4) but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the , ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation (5). Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER (6). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. , Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug'ml, Optimal dilutions to be determined by the researcher. Positive Control: A-20 cell lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer., ,
Keywords: | Anti-IRE1a, Anti-hIRE1p, Anti-Ire1-alpha, EC=3.1.26.-, EC=2.7.11.1, Anti-Endoribonuclease, Anti-Inositol-requiring protein 1, Anti-Serine/threonine-protein kinase, Anti-Endoplasmic reticulum-to-nucleus signaling 1 |
Supplier: | United States Biological |
Supplier-Nr: | I8604-16 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide IRE1p antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IRE1p (Genbank accession No. O75460). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08852 | Matching products |
UniProt ID : | O75460 | Matching products |
Gene ID | GeneID 2081 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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