Anti-Interleukin 3 Receptor alpha (IL-3RA, IL-3R alpha, IL-3R, IL3RAX, IL3RX, IL3RAY, IL3RY, CD123,

Anti-Interleukin 3 Receptor alpha (IL-3RA, IL-3R alpha, IL-3R, IL3RAX, IL3RX, IL3RAY, IL3RY, CD123,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I7663-47A.100 100 µg - -

3 - 19 business days*

623.00€
 
IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic... more
Product information "Anti-Interleukin 3 Receptor alpha (IL-3RA, IL-3R alpha, IL-3R, IL3RAX, IL3RX, IL3RAY, IL3RY, CD123,"
IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either common beta chain (CDw131) or the IL3RB chain to form high affinity heterodimeric IL3 receptors. CDw131 can complex with the Alpha subunits of the mouse IL3R, IL5R and GMCSFR to form high affinity receptors, while the IL3RB subunit is specific for IL3 but binds with low affinity. IL3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. It is present in Hematopoietic progenitors, basophils, mast cells and megakaryocytes. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry (Intrecellular): 1:10-1:1000. Use 1ug to label 1x10e6 cells in 100ul, Western Blot: 1:100-1:2000. Detects a band at ~70kD, Immunohistochemistry (Frozen): 1:10-1:500, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: I7663-47A

Properties

Application: FC, IHC, WB
Antibody Type: Monoclonal
Clone: 8L446
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Tissue / cell preparation. IL3R transfected COS cells.
Purity: Purified by Protein G affinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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