Anti-Integrin alpha 4 / ITGA4

Anti-Integrin alpha 4 / ITGA4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R31960 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. ITGA4/Integrin alpha4 is an integrin alpha... more
Product information "Anti-Integrin alpha 4 / ITGA4"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. ITGA4/Integrin alpha4 is an integrin alpha subunit. It makes up half of the alpha4beta1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. ITGA4 is also mapped to 2q31-q32 by fluorescence in situ hybridization. Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). [The UniProt Consortium]
Keywords: Anti-CD49D, Anti-CD49d, Anti-ITGA4, Anti-Integrin alpha-4, Anti-Integrin alpha-IV, Anti-VLA-4 subunit alpha, Anti-CD49 antigen-like family member D, Integrin alpha 4 Antibody / ITGA4
Supplier: NSJ Bioreagents
Supplier-Nr: R31960

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat
Immunogen: Amino acids MWKAGFFKRQYKSILQEENRRDSWSYINS K of human ITGA4 were used as the immunogen for the Integrin alpha 4 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Integrin alpha 4 / ITGA4"
Write a review
or to review a product.
Viewed