Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7884-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V7884-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Interleukin-4 (IL-4), also... more
Product information "Anti-IL-4, clone IL4/1597"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. Protein function: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964). [The UniProt Consortium]
Keywords: | Anti-Il4, Anti-Il-4, Anti-IL-4, Anti-BSF-1, Anti-Interleukin-4, Anti-IGG1 induction factor, Anti-B-cell growth factor 1, Anti-B-cell stimulatory factor 1, Anti-Lymphocyte stimulatory factor 1, Anti-B-cell IgG differentiation factor, IL-4 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7884 |
Properties
Application: | ELISA |
Antibody Type: | Monoclonal |
Clone: | IL4/1597 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant full-length human IL-4 protein |
Format: | Purified |
Database Information
KEGG ID : | K05430 | Matching products |
UniProt ID : | P07750 | Matching products |
Gene ID | GeneID 16189 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed