Anti-IL-4, clone IL4/1597

Anti-IL-4, clone IL4/1597
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7884-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V7884-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Interleukin-4 (IL-4), also... more
Product information "Anti-IL-4, clone IL4/1597"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. Protein function: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964). [The UniProt Consortium]
Keywords: Anti-Il4, Anti-Il-4, Anti-IL-4, Anti-BSF-1, Anti-Interleukin-4, Anti-IGG1 induction factor, Anti-B-cell growth factor 1, Anti-B-cell stimulatory factor 1, Anti-Lymphocyte stimulatory factor 1, Anti-B-cell IgG differentiation factor, IL-4 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7884

Properties

Application: ELISA
Antibody Type: Monoclonal
Clone: IL4/1597
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant full-length human IL-4 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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