Anti-IL10

Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB17501.50 50 µl - -

9 - 20 business days*

352.00€
G-CAB17501.100 100 µl -

9 - 20 business days*

448.00€
 
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system... more
Product information "Anti-IL10"
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines including granulocyte-macrophage colony- stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G- CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co- stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. [The UniProt Consortium]
Keywords: Anti-IL10, Anti-CSIF, Anti-IL-10, Anti-Interleukin-10, Anti-Cytokine synthesis inhibitory factor, IL10 Rabbit pAb
Supplier: Assay Genie
Supplier-Nr: CAB17501

Properties

Application: IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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