Anti-ICOS (Inducible T-cell Costimulator, Inducible T-cell Co-stimulator, Activation-inducible Lymph

Anti-ICOS (Inducible T-cell Costimulator, Inducible T-cell Co-stimulator, Activation-inducible Lymph
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I0650-01A2.120 120 tests - -

1 - 19 business days

589.00€
 
The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28... more
Product information "Anti-ICOS (Inducible T-cell Costimulator, Inducible T-cell Co-stimulator, Activation-inducible Lymph"
The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells (1). Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement (2). Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for ICOS. Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain (4). Applications: Suitable for use in FLISA and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Supplier: United States Biological
Supplier-Nr: I0650-01A2

Properties

Application: FLISA, FC
Antibody Type: Monoclonal
Clone: 7H152
Conjugate: FITC
Host: Mouse
Reactivity: Human
Immunogen: Human HPB-MLT cells, ICOS-muIg fusion protein
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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