Anti-ICOS (Inducible T-cell Costimulator, Inducible T-cell Co-stimulator, Activation-inducible Lymph

Anti-ICOS (Inducible T-cell Costimulator, Inducible T-cell Co-stimulator, Activation-inducible Lymph
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I0650-01A1.100 100 µg - -

1 - 19 business days

465.00€
 
The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28... more
Product information "Anti-ICOS (Inducible T-cell Costimulator, Inducible T-cell Co-stimulator, Activation-inducible Lymph"
The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells (1). Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement (2). Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for ICOS. Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain (4). Applications: Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: I0650-01A1

Properties

Application: ELISA, FC
Antibody Type: Monoclonal
Clone: 7H152
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human HPB-MLT cells, ICOS-muIg fusion protein
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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