Anti-ICAD (DNA Fragmentation Factor Subunit alpha, DNA Fragmentation Factor 45 kDa Subunit, DFF-45,

Anti-ICAD (DNA Fragmentation Factor Subunit alpha, DNA Fragmentation Factor 45 kDa Subunit, DFF-45,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I0505-05U.50 50 µg - -

1 - 19 business days

650.00€
 
Apoptosis is related to many diseases and induced by a family of cell death receptors and their... more
Product information "Anti-ICAD (DNA Fragmentation Factor Subunit alpha, DNA Fragmentation Factor 45 kDa Subunit, DFF-45,"
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45kD DNA fragmentation factor (DFF45) was identified recently that was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD. DFF45/ICAD have short forms that were termed DFF35 and ICADs, respectively. Upon cleavage of DFF45/ICAD, the caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000, Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: I0505-05U

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to aa2-21 of human DFF45 conjugated to KLH.
Format: Highly Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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