Anti-HSPD1 (60 kDa Heat Shock Protein, Mitochondrial, 60 kDa Chaperonin, Chaperonin 60, CPN60, Heat

Anti-HSPD1 (60 kDa Heat Shock Protein, Mitochondrial, 60 kDa Chaperonin, Chaperonin 60, CPN60, Heat
Item number Size Datasheet Manual SDS Delivery time Quantity Price
H1834-25V.50 50 µg - -

1 - 19 business days

650.00€
 
HSP60, a 60kD member of Chaperonin family, is a mitochondrial protein that participates in... more
Product information "Anti-HSPD1 (60 kDa Heat Shock Protein, Mitochondrial, 60 kDa Chaperonin, Chaperonin 60, CPN60, Heat"
HSP60, a 60kD member of Chaperonin family, is a mitochondrial protein that participates in protein folding, transport and secretion. HSP60 is a multi-functional protein whose roles include accelerating the maturation of pro-caspase 3 during apoptosis, LPS-binding, acting as a ligand for innate immune system and also binding to the surface of innate immune cells and stimulating proinflammatory reactivity. It induces the expression of IL-12 and IL-15 and also induces release of TNF-alpha, NO and IL-6. Reports suggest interaction of Hsp60 with integrin molecules during metastasis. Mutations in Hsp60 gene cause autosomal recessive spastic paraplegia 13. Hsp60 has been found to be involved in development of auto-immune disorders such as Rheumatoid arthritis, insulin-dependent diabetes mellitus, systemic sclerosis and atherosclerosis. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: H1834-25V

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to aa31-50 of human HSP60.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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