Anti-HSF1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-10374.20 20 µl -

7 - 16 business days*

71.00€
E-AB-10374.60 60 µl -

7 - 16 business days*

143.00€
E-AB-10374.120 120 µl -

7 - 16 business days*

238.00€
E-AB-10374.200 200 µl -

7 - 16 business days*

396.00€
 
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes... more
Product information "Anti-HSF1"
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated witHuman, Mouseultichaperone complexes, is a major repressor of this gene. Protein function: Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage- dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). [The UniProt Consortium]
Keywords: Anti-HSF 1, Anti-HSTF1, Anti-HSTF 1, Anti-Heat shock factor protein 1, Anti-Heat shock transcription factor 1, HSF1 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-10374

Properties

Application: IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Recombinant protein of human HSF1
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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