Anti-Hrs, clone 19-5

Anti-Hrs, clone 19-5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
MM-0061-P 50 µg - -

3 - 8 business days*

488.00€
 
Protein function: Involved in intracellular signal transduction mediated by cytokines and growth... more
Product information "Anti-Hrs, clone 19-5"
Protein function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. [The UniProt Consortium]
Keywords: Anti-Hrs, Anti-HRS, Anti-HGS, Anti-Protein pp110, Anti-Hepatocyte growth factor-regulated tyrosine kinase substrate
Supplier: MediMabs
Supplier-Nr: MM-0061-P

Properties

Application: WB, IHC, IP
Antibody Type: Monoclonal
Clone: 19-5
Conjugate: No
Host: Mouse
Species reactivity: human, rat, mouse, monkey
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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