Anti-HOIL-1L/RBCK1

Anti-HOIL-1L/RBCK1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-11-6007-25 25 µg -

3 - 11 business days*

134.00€
 
RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1) is a transcription factor belonging to... more
Product information "Anti-HOIL-1L/RBCK1"
RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1) is a transcription factor belonging to the RING-IBR protein family. It shuttles between the nucleus and cytoplasm, possessing both the nuclear export and localization signals within its amino acid sequence. RBCK1 deficiency causes polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy. RBCK1 negatively regulates the cellular antiviral response. RBCK1 regulates cell cycle progression and proliferation of ERalpha (estrogen receptor alpha)-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1. Protein function: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. [The UniProt Consortium]
Keywords: Anti-RBCK1, Anti-HOIL-1, Anti-C20orf18, Anti-RING finger protein 54, Anti-HBV-associated factor 4, Anti-Heme-oxidized IRP2 ubiquitin ligase 1, Anti-Hepatitis B virus X-associated protein 4, Anti-RING-type E3 ubiquitin transferase HOIL-1, Polyclonal Antibo
Supplier: Abeomics
Supplier-Nr: 11-6007-25

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse)
Immunogen: A partial length recombinant HOIL-1L/RBCK1 protein (amino acids 121-333) was used as the immunogen for this antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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