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Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
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*1 Offer expires 30/06/2024
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Noxa is a BH3-only pro-apoptotic protein that mediates apoptosis by specifically inhibiting the... more
Product information "Anti-hNOXA (Clone: ABM16G6)"
Noxa is a BH3-only pro-apoptotic protein that mediates apoptosis by specifically inhibiting the anti-apoptotic Bcl-2 family member Mcl-1. It consists of 54 amino acids with one BH3 domain. The gene for NOXA is a target of p53. In response to cellular stress Noxa is induced by p53 and mediates p53-induced apoptosis. But more recently, it has been shown that NOXA can also be induced independently of p53 by other transcription factors such as p73 and E2F1. Noxa is also found to be induced by hypoxia-inducible factor (HIF-1) and mediates HIF-1 induced hypoxic cell death. Noxa is commonly upregulated in melanomas, and is associated with melanoma development and progression. Increase in Noxa expression is driven by oncogenic activation of MEK/ERK signaling through the transcription factor CREB (cAMP responsive element binding protein). Protein function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. [The UniProt Consortium]
Keywords: | Anti-NOXA, Anti-PMAIP1, Anti-Protein Noxa, Anti-PMA-induced protein 1, Anti-Immediate-early-response protein APR, Anti-Phorbol-12-myristate-13-acetate-induced protein 1, Monoclonal Antibody to hNOXA (Clone: ABM16G6) |
Supplier: | Abeomics |
Supplier-Nr: | 10-1031 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | ABM16G6 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Full length recombinant protein of NOXA was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10131 | Matching products |
UniProt ID : | Q13794 | Matching products |
Gene ID | GeneID 5366 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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