Anti-HK1 / Hexokinase 1, clone 4B7

Anti-HK1 / Hexokinase 1, clone 4B7
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5660 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Hexokinase-1 (HK1) is an enzyme that in... more
Product information "Anti-HK1 / Hexokinase 1, clone 4B7"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Hexokinase-1 (HK1) is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. It is mapped to 10q22.1. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. Protein function: Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). [The UniProt Consortium]
Keywords: Anti-HK I, Anti-Hexokinase-1, Anti-Hexokinase-A, Anti-Hexokinase type I, Anti-Brain form hexokinase, HK1 Antibody / Hexokinase 1
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5660

Properties

Application: WB, IHC (paraffin), IF, FC
Antibody Type: Monoclonal
Clone: 4B7
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: Recombinant human protein (amino acids D17-R323)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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