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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
AG-20T-0400-C100 | 100 µg | - |
3 - 9 business days* |
10 %
|
369.00€
332.10€ |
Protein function: Transcriptional repressor of genes that require a bHLH protein for their... more
Product information "Anti-HES1, clone 7H11"
Protein function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. [The UniProt Consortium] The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.
Keywords: | Anti-hHL, Anti-HES1, Anti-BHLHB39, Anti-bHLHb39, Anti-Hairy homolog, Anti-Hairy-like protein, Anti-Transcription factor HES-1, Anti-Hairy and enhancer of split 1, Anti-Class B basic helix-loop-helix protein 39 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20T-0400 |
Properties
Application: | ELISA, WB, IP |
Antibody Type: | Monoclonal |
Clone: | 7H11 |
Conjugate: | No |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant human Hes1 protein fused to a His-tag |
Purity: | >95% |
Format: | Ammonium Sulfate Precipitated |
Database Information
KEGG ID : | K06054 | Matching products |
UniProt ID : | Q14469 | Matching products |
Gene ID | GeneID 3280 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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