Anti-HDAC1 (Histone Deacetylase-1)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-879 100 µg - -

6 - 10 business days*

684.00€
 
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of... more
Product information "Anti-HDAC1 (Histone Deacetylase-1)"
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. [The UniProt Consortium]
Keywords: Anti-HD1, Anti-HDAC1, Anti-RPD3L1, EC=3.5.1.98, Anti-Histone deacetylase 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-879

Properties

Application: ELISA, IHC, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: human, mouse, rat, chimpanzee)
Immunogen: synthetic peptide corresponding to aa 466-482 of human CaM kinase II.
MW: 65 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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