Anti-HDAC1

Anti-HDAC1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-J16 100 µg - -

6 - 10 business days*

684.00€
 
Anti-HDAC1 was affinity purified from monospecific antiserum by immunoaffinity chromatography.... more
Product information "Anti-HDAC1"
Anti-HDAC1 was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is specific towards HDAC1. A BLAST analysis was used to suggest cross-reactivity with Human, Mouse, Rat, and Primate based on 100% sequence homology. Cross-reactivity with HDAC1 from other sources has not been determined. Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. [The UniProt Consortium]
Keywords: Anti-HD1, Anti-HDAC1, Anti-RPD3L1, EC=3.5.1.98, Anti-Histone deacetylase 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-J16

Properties

Application: ELISA, IHC, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat, primates
Immunogen: synthetic peptide corresponding to an internal region of human HDAC1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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