Anti-Hck

Anti-Hck
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG59607.100 100 µl - -

6 - 14 business days*

624.00€
 
Protein function: Non-receptor tyrosine-protein kinase found in hematopoietic cells that... more
Product information "Anti-Hck"
Protein function: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. [The UniProt Consortium]
Keywords: Anti-HCK, Anti-p59Hck, Anti-p61Hck, EC=2.7.10.2, Anti-p59-HCK/p60-HCK, Anti-Hemopoietic cell kinase, Anti-Hematopoietic cell kinase, Anti-Tyrosine-protein kinase HCK
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG59607

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant fusion protein corresponding to aa. 324-505 of Human Hck (NP_001165600.1)
MW: 57 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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