Anti-HAS1

Anti-HAS1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030288.100 100 µl - -

3 - 19 business days*

682.00€
 
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide... more
Product information "Anti-HAS1"
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Applications: Western Bloting: 1:500-1:2000., Immunofluorescence: 1:200-1:1000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-HAS, Anti-HAS1, Anti-HuHAS1, EC=2.4.1.212, Anti-HA synthase 1, Anti-Hyaluronan synthase 1, Anti-Hyaluronate synthase 1, Anti-Hyaluronic acid synthase 1
Supplier: United States Biological
Supplier-Nr: 030288

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 13B366
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Purified recombinant fragment of human HAS1 expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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