Anti-GRB2 (Growth Factor Receptor-bound Protein 2, Adapter Protein GRB2, Protein Ash, SH2/SH3 Adapte

Anti-GRB2 (Growth Factor Receptor-bound Protein 2, Adapter Protein GRB2, Protein Ash, SH2/SH3 Adapte
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G8960-02J.50 50 µg - -

1 - 19 business days

650.00€
 
Grb2 is an adaptor protein which has no enzymatic activity, however, Grb2 plays an important role... more
Product information "Anti-GRB2 (Growth Factor Receptor-bound Protein 2, Adapter Protein GRB2, Protein Ash, SH2/SH3 Adapte"
Grb2 is an adaptor protein which has no enzymatic activity, however, Grb2 plays an important role in signaling cascades by physically linking other proteins through its phosphotyrosine-binding SH2 domain and its proline-binding SH3 domain. Grb2 associates with the guanine nucleotide exchange factor Sos via its SH3 domain. In response to cell stimulation with growth factors, growth factor receptors are autophosphorylated on cytoplasmic tyrosine residues. Grb2's association with these tyrosine residues via its SH2 domain permits the localization of Sos with the growth factor receptor near the cell membrane. Sos is then able to activate the membrane associated protein Ras which in turn activates the MAPK cascade and influences gene expression. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000, Western Blot: 1-3ug/ml, Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: G8960-02J

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Human
Immunogen: Synthetic peptide corresponding to PRNYVTPVNRNV from C-Terminus of human GRB2 conjugated to KLH.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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