Anti-GRB10

Anti-GRB10
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-735A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-735A 100 µl (100 µg) -

3 - 9 business days

443.00€
 
Protein function: Adapter protein which modulates coupling of a number of cell surface receptor... more
Product information "Anti-GRB10"
Protein function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin- stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. [The UniProt Consortium]
Keywords: Anti-GRB10, Anti-GRBIR, Anti-GRB10 adapter protein, Anti-Insulin receptor-binding protein Grb-IR, Anti-Growth factor receptor-bound protein 10
Supplier: Bethyl Laboratories
Supplier-Nr: A301-735A

Properties

Application: IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-735A maps to a region between residue 100 and 150 of human growth factor receptor-bound protein 10 using the numbering given in entry NP_005302.3 (GeneID 2887).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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