Anti-Granzyme B (human), Rabbit Monoclonal (RM441)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
REV-31-1332-00-R100 100 µl - -

3 - 9 business days*

483.00€
 
Protein function: Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells... more
Product information "Anti-Granzyme B (human), Rabbit Monoclonal (RM441)"
Protein function: Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927). It cleaves after Asp (PubMed:8258716, PubMed:1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore- forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (PubMed:9852092). [The UniProt Consortium]
Keywords: Anti-C11, Anti-HLP, Anti-SECT, Anti-CTSGL1, Anti-CTLA-1, Anti-Granzyme B, Anti-Granzyme-2, Anti-Fragmentin-2, Anti-Cathepsin G-like 1, Anti-Lymphocyte protease, Anti-Human lymphocyte protein, Anti-T-cell serine protease 1-3E, Anti-Granzyme B Rabbit Monocl
Supplier: RevMAb Biosciences
Supplier-Nr: 31-1332-00

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: RM441
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: peptide corresponding to the C-terminus of Granzyme B
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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