Anti-Granzyme B, clone GZMB/3056

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7835-20UG 20 µg - -

3 - 10 business days*

251.00€
NSJ-V7835-100UG 100 µg - -

3 - 10 business days*

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Granzyme B is a member of the... more
Product information "Anti-Granzyme B, clone GZMB/3056"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease. Protein function: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. [The UniProt Consortium]
Keywords: Anti-HLP, Anti-C11, Anti-SECT, Anti-CGL1, Anti-GZMB, Anti-CTLA-1, Anti-CTSGL1, Anti-Granzyme-2, Anti-Granzyme B, Anti-Fragmentin-2, EC=3.4.21.79, Anti-Cathepsin G-like 1, Anti-Lymphocyte protease, Anti-Human lymphocyte protein, Granzyme B Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7835-20UG

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: GZMB/3056
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A recombinant human partial protein (amino acids 73-187)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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