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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G8250-37A.100 | 100 µl | - | - |
3 - 19 business days* |
682.00€
|
The highly conserved receptor for activated C kinase 1 (RACK1), homologous to the b subunit of... more
Product information "Anti-GNB2L1 (Guanine Nucleotide Binding Protein Subunit beta-2-like 1, Guanine Nucleotide-binding Pr"
The highly conserved receptor for activated C kinase 1 (RACK1), homologous to the b subunit of heterotrimeric G-proteins, was originally identified through its binding of active PKCbII and other classical PKC isoforms. RACK1 is a scaffold protein that recruits PKC and a wide range of other proteins to specific subcellular locations, promoting the formation of multiprotein complexes to induce and integrate various signaling pathways. One example of this is its enhancement of PKC-dependent JNK activation. RACK1 protein also resides in the eukaryotic ribosome, suggesting the possibility that RACK1 participates in the assembly of signaling complexes that regulate translation as well. RACK1 binds the SH2 domain of Src, and phosphorylation of RACK1 by Src occurs at Tyr228 after PKC activation. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% nonfat dry milk, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Immunoprecipitation: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Receptor for activated C kinase, Anti-Human lung cancer oncogene 7 protein, Anti-Receptor of activated protein kinase C 1, Anti-Cell proliferation-inducing gene 21 protein, Anti-Guanine nucleotide-binding protein subunit beta-2-like 1 |
Supplier: | United States Biological |
Supplier-Nr: | G8250-37A |
Properties
Application: | IP, WB |
Antibody Type: | Monoclonal |
Clone: | D59D5 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, monkey, mouse, rat |
Immunogen: | Synthetic peptide corresponding to central residues of human GNB2L1. |
Format: | Supernatant |
Database Information
KEGG ID : | K14753 | Matching products |
UniProt ID : | P63244 | Matching products |
Gene ID | GeneID 10399 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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