Anti-Glial Derived Neurotrophic Factor (GDNF, Glial cell line-derived neurotrophic factor, Astrocyte

Anti-Glial Derived Neurotrophic Factor (GDNF, Glial cell line-derived neurotrophic factor, Astrocyte
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G2036-01H.100 100 µl - -

3 - 19 business days

557.00€
 
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent... more
Product information "Anti-Glial Derived Neurotrophic Factor (GDNF, Glial cell line-derived neurotrophic factor, Astrocyte"
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson?s disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. , Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer, disulfide-linked. Cellular Localization: Secreted protein. Alternative Products: 2 named isoforms produced by alternative splicing. , DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS), also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Belongs to the TGF-beta family. GDNF subfamily. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: G2036-01H

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Sheep
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant human GDNF.
Purity: Serum
Format: Serum

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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