Anti-GLI3

Item number	Size	Manual	Delivery time	Price
A303-417A-T	20 µl (2 blots)	-	3 - 9 business days*	131.00€
A303-417A-M	100 µl (10 blots)	-	3 - 9 business days*	313.00€
A303-417A	100 µl (100 µg)	-	3 - 9 business days*	465.00€

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Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic... more

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Product information "Anti-GLI3"

Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. [The UniProt Consortium]

Keywords:	Anti-GLI3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-417A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Reactivity:	Human (Expected: Mouse, Chimpanzee)
Immunogen:	synthetic peptide. The epitope recognized by A303-417A-T maps to a region between residue 875 and 925 of human GLI Family Zinc Finger 3 using the numbering given in entry NP_000159.3 (GeneID 2737).
Format:	Antigen Affinity Purified