Anti-GCN1L1

Anti-GCN1L1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB13075.100 100 µl -

9 - 20 business days*

314.00€
 
WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Acts as a positive activator of the... more
Product information "Anti-GCN1L1"
WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes, during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [The UniProt Consortium]
Keywords: Anti-HsGCN1, Anti-GCN1-like protein 1, Anti-Translational activator GCN1, Anti-eIF-2-alpha kinase activator GCN1, Anti-GCN1 eIF-2-alpha kinase activator homolog, Anti-General control of amino-acid synthesis 1-like protein 1, GCN1L1 Polyclonal Antibody (CA
Supplier: Assay Genie
Supplier-Nr: CAB13075

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2462-2671 of human GCN1L1 (NP_006827.1).
MW: 265 kD
Format: Affinity Purified

Database Information

UniProt ID : Q92616 | Find alternatives
Gene ID GeneID 10985 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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