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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G8600-02Y.200 | 200 µl | - | - |
3 - 19 business days* |
728.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GßL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates... more
Product information "Anti-GBL (G Protein beta Subunit-like, Gable, Mammalian Lethal with SEC13 Protein 8, mLST8, LST8, MG"
GßL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with GßL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of GßL to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:250-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-TORC subunit LST8, Anti-G protein beta subunit-like, Anti-Mammalian lethal with SEC13 protein 8, Anti-Target of rapamycin complex subunit LST8 |
Supplier: | United States Biological |
Supplier-Nr: | G8600-02Y |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide selected from the center region of human GBL (KLH). |
Format: | Purified |
Database Information
KEGG ID : | K08266 | Matching products |
UniProt ID : | Q9BVC4 | Matching products |
Gene ID | GeneID 64223 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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