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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32378-50 | 50 µl | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme that catalyzes the conversion of... more
Product information "Anti-GAPDH (C-Term) Rabbit Monoclonal Antibody - Biotinylated (Clone RM114)"
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme that catalyzes the conversion of glyceraldehyde-3-phosphate (Cay-17865) to 1,3-bisphosphoglycerate during glycolysis and is involved in numerous additional cellular processes, including intracellular trafficking, receptor-mediated signaling, apoptosis, DNA repair, and the oxidative stress response. It exists as a tetramer and is composed of an N-terminal domain, which contains binding sites for NAD+, phosphatidylserine, RNA, and glutathione, and a C-terminal catalytic domain. GAPDH is widely expressed and primarily localizes to the cytosol, where it has roles in glycolysis and intracellular trafficking. It also localizes to the nucleus, mediating DNA integrity, gene transcription, and apoptosis, as well as to cellular membranes, where it has roles in membrane fusion and iron transport. GAPDH expression is increased by insulin, hypoxia-inducible factor-1 (HIF-1), p53, and nitric oxide (NO) and decreased by acetylated histones. Aberrant mRNA and protein levels of GAPDH have been found in tumor biopsies from patients with a variety of cancers, including lung, renal cell, colorectal, or breast cancer. Cayman's GAPDH (C-Term) Rabbit Monoclonal Antibody - Biotinylated (Clone RM114) can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), chromatin immunoprecipitation (ChIP), and Western blot (WB) applications. The antibody recognizes the C-terminal region of GAPDH at approximately 36 kDa.Synonyms: G3PD Protein, Human, GAPD Protein, Human, Glyceraldehyde-3-phosphate dehydrogenase, HEL-S-162eP Protein, Peptidyl-cysteine S-nitrosylase. Immunogen: Peptide from the C-terminal region of GAPDH. Clone Designation: RM114. MW: ~36 kDa. Formulation: (Request formulation change), 50 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ICC, IHC, IP, ChIP, WB. Cross Reactivity: (+) GAPDH.
Keywords: | G3PD Protein, Human, GAPD Protein, Human, HEL-S-162eP Protein, Peptidyl-cysteine S-nitrosylase |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32378 |
Properties
Application: | ICC, IHC, IP, ChIP, WB |
Antibody Type: | Monoclonal |
Clone: | RM114 |
Conjugate: | Biotin |
Host: | Rabbit |
Immunogen: | Peptide from the C-terminal region of GAPDH |
Format: | Purified |
Database Information
KEGG ID : | K00134 | Matching products |
UniProt ID : | P04406 | Matching products |
Gene ID | GeneID 2597 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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